6 While the association between sleep quality and asthma control is well established, the role of nocturnal cough is less clear.Ī first cross-sectional study has indicated that nocturnal cough frequency might be a valid marker for asthma control, 7 rendering it a potentially useful parameter for disease self-monitoring. 2 It has been shown that ‘asthma control’, the extent to which asthma symptoms are controlled by treatment, 2 is statistically associated with sleep quality. In asthma, coughing and other symptoms tend to get worse at night and often cause awakenings. 2 Coughing is perceived by patients as a troublesome symptom, 3 predicts asthma severity 4 and indicates a worse prognosis. Common symptoms include wheezing, shortness of breath, chest tightness and coughing. According to the WHO, 235 million people suffer from asthma with 383 000 asthma-related deaths in 2015 1. In the second stage, patient-reported asthma control will be predicted in a mixed effects regression model with nocturnal cough frequencies and sleep quality of past nights as the main predictors.Īsthma, a chronic respiratory disease, is one of the most prevalent chronic conditions.
Analysis of the first stage is concerned with the prevalence and trends of nocturnal cough and the accuracies of smartphone-based automated detection of nocturnal cough and sleep quality. Relatively unrestrictive eligibility criteria for study participation are set to support external validity of study results. In addition, nocturnal coughs from smartphone microphone recordings will be labelled and counted by human annotators. Asthma control will be assessed by the Asthma Control Test and sleep quality by means of the Pittsburgh Sleep Quality Index. On the first and the last study day, a participant’s asthma will be clinically assessed, including spirometry and fractionated exhaled nitric oxide levels.
Sensor and questionnaire data of 94 individuals with asthma will be recorded for 28 nights by means of a smartphone. The study is a multicentre, longitudinal observational study with two stages.
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